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Non-invasive imaging for biomedical problems

  The laboratory is working to develop and improve non-invasive methods for studying biological objects, as well as diagnosing pathologies using digital holographic microscopy methods. In particular, in close cooperation with the Physico-Technical Institute. AF Ioffe, as well as the Institute of Cytology, studies are carried out to determine the morphological characteristics of living cells and the dynamics of their changes in the course of cell death processes of various types. The method of digital holographic microscopy makes it possible to obtain more complete information about the object under study in comparison with the methods of ordinary microscopy (Fig. 1), which allows obtaining quantitative data on the volume and thickness of the cell. The findings can be used, for example, to describe necrosis processes (Figure 2) [1] or cell heating (Figure 3) [2]. Currently, work is underway to develop and use this method to study the change in other morphological characteristics of the cell during the course of various intracellular processes.

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[1] Belashov A. V. et al. Digital holographic microscopy in label-free analysis of cultured cells’ response to photodynamic treatment //Optics Letters. – 2016. – Т. 41. – №. 21. – С. 5035-5038.